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RAD-1091, a groundbreaking, easily ingestible selective estrogen receptor degrader, shows unparalleled anticancer effects in breast cancer xenograft models. This includes multiple ER+ breast cancer models that have developed resistance to CDK4/6 inhibitors. It is equally effective to provide significant relief to postmenopausal women with moderate to severe vasomotor symptoms.
This powerful adversary of ER-positive breast cancer cell multiplication selectively attaches to and decomposes the estrogen receptor. It is important to note here that RAD-1901 (also known as Elacestrant) displays growth inhibition in cells resistant to all three approved CDK4/6i in both ESR1 wild-type and mutant backgrounds. It serves as an endocrine backbone for rational combinations to combat resistance.
Estrogen is the primary female hormone, and it plays a crucial role in the development and maintenance of female reproductive organs. It also affects other tissues and organs, including the bones, breasts, and heart.
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