NMN Benefits At A Glance-Advantages Of Nicotinamide Mononucleotide

In the last few years, scientists and fitness enthusiasts have been appreciating the innumerable benefits of Nicotinamide Mononucleotide (NMN). Let us read more about some of the most amazing NMN benefits to gain a clear and complete understanding about this versatile compound.

A precursor to nicotinamide adenine dinucleotide (NAD+), Nicotinamide mononucleotide can be described as a compound that is present in every body cell. It can also be defined as a bioactive nucleotide that gets formed by the reaction between a nucleoside including nicotinamide and ribose and a phosphate group. A fairly acidic and water-soluble compound, NMN has the molecular weight of 334.22g/mol.

An intermediate of NAD+ biosynthesis, NMN is also clinically recommended to treat health conditions such as obesity, heart failure, cerebral and cardiac ischemia, and cardiomyopathies. It also displays great benefits to treat acute kidney injury, alcoholic liver disease, retinal degeneration, macular degeneration, and corneal injury.

It is worthwhile to note here that NAD+ plays a crucial role in vital processes such as gene expression, energy metabolism, and the regulation of mitochondrial functioning. However, NAD+ levels tend to decline with growing age as the body keeps utilizing a significant portion of this compound. Meanwhile, the production of NAD+ starts reducing with growing age. This depletion can negatively impact health status as we age. This, in turn, can considerably increase the risk of age-related diseases like Alzheimer's disease and type 2 diabetes.

Benefits Of Nicotinamide Mononucleotide (NMN)

One of the biggest advantages of Nicotinamide mononucleotide is its unique ability to significantly increase the levels of NAD+ in the body. NMN supplementation can be highly beneficial to overweight, older adults. NMN benefits also include dramatic improvements in the levels of energy, physical performance, muscle mass, and muscle size.

In addition to these advantages, NMN benefits also include improved metabolic health parameters. This includes the body's improved sensitivity to insulin. NMN supplementation can also positively impact triglyceride levels which, in turn, improve insulin, blood sugar, and lipid levels. Studies have also demonstrated that NMN can also help in the maintenance of healthy insulin sensitivity, plasma blood profile, energy metabolism, physical activity, and other physiopathologies. Moreover, NMN benefits also include averted alterations in age-associated gene expression in the primary metabolic organs while improving mito-nuclear protein imbalance as well as mitochondrial oxidative metabolism in skeletal muscles. Also, NMN supplementation is known to restore minimized contents of renal protective molecule, SIRT1 and its cofactor, NAD+.

Nicotinamide Mononucleotide also plays a crucial role to improve cellular rejuvenation, energy metabolism, mitochondrial function, DNA repair, cellular energy, and telomere extension. Considered to be one of the best natural NAD+ enhancers, this NAD+ booster also helps in reducing oxidative stress and improving muscle function so the body can also perform to its fullest. NMN benefits also include improved and youthful skin and a variety of brain health benefits. Characterized by powerful anti-inflammatory effects, NMN also prevents the reduction and inhibition of NAMPT-mediated NAD+ biosynthesis.

Nicotinamide Mononucleotide advantages also include prevented interruption of mitochondrial regulation of PCG-1α/β-independent pathway of oxidative-phosphorylation that can cause pseudohypoxia. Nicotinamide Mononucleotide advantages also include the inhibition of hypoxia-inducible factor 1 alpha (HIF-1). All in all, NMN supplementation can reinstate NAD+ levels to prevent age-related diseases and reverse the aging process.

It can also be useful to treat NAD+ depletion that could have otherwise resulted in DNA damage, inflammatory conditions, cognitive impairment, oxidative stress, and the downregulation of energy production in mitochondria. By doing this, it proves to be an excellent choice for individuals who are diagnosed with severe and life-debilitating health conditions such as Parkinson's disease, diabetes mellitus, cancer, hypertension, neurodegenerative diseases, age- and diet-induced type 2 diabetes, and atherosclerosis.

The list of NMN benefits doesn't end here. Nicotinamide Mononucleotide also demonstrates unmatched efficacy to treat aging and signs of aging such as fine lines, wrinkles, and age spots. NMN also helps in treating and preventing other signs of aging such as cellular senescence, stem cell exhaustion, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, and altered intercellular communication.

Nicotinamide Mononucleotide advantages also include disrupted DBC1-PARP1 complex, increased hepatic NAD+ contents, and reduced DNA damage while protecting the body against alterations in hemoglobin and white blood cell count including lymphocytes. As a sirtuins activating agent, NMN can offer protection against health conditions such as dry eye, macular degeneration, and glaucoma. This is simply because NMN treats the reduction of blood flow and capillary density [by triggering sirtuin deacylases (SIRT1-7)] that happens with aging. Also, NMN supplementation can significantly enhance NAD levels in liver and gastrocnemius tissues.

Furthermore, NMN benefits include protection against age-related disorders like skeletal aging that is commonly associated with increased adipogenesis and reduced osteogenesis by regulating mesenchymal stromal cells (MSCs). This is primarily because NMN has the unique ability of self-renewal of MSCs along with strengthened osteogenesis and decreased adipogenesis. Nicotinamide Mononucleotide also serves as a potential and promising therapeutic agent for skeletal aging that helps in regulating bone-fat imbalance via SIRT1 and rejuvenation and expansion of aged MSCs.

NMN is also known to improve muscle glucose metabolism and exerts positive effects on brain function, skin, liver, muscle, and metabolism. NMN benefits also include improved vascular health, immune system function, lifespan, bone structure, and reproduction. It also improves aerobic capacity in athletes, bodybuilders, and fitness enthusiasts. NMN also helps in reversing vascular aging by promoting the restoration of blood vessel elasticity and reducing cellular senescence that result in the alleviation of hypertension. Also, NMN can significantly improve the tumor-inhibiting capabilities of natural killer cell therapy, CAR-T cell therapy, and PD-1 mediated therapy.

Nicotinamide Mononucleotide advantages also include protection against age-related kidney deterioration and the reversal of intestinal aging. It also helps in promoting bone formation and the rejuvenation of bone stem cells. Not only this, Nicotinamide Mononucleotide is also known to improve the age-related decline in oocyte quality and count while improving female fertility.

NMN benefits also include reduced fat tissue inflammation and the prevention of cardiovascular, cognitive, and metabolic decline. It also helps in improving the quality of sleep and rejuvenating stem cells while improving exercise endurance and muscle strength.

NMN Side Effects

As far as NMN side effects are concerned, the compound is found to be relatively safe in doses of between 100-500mg. If you experience any abnormality after using NMN, you should immediately discontinue the use of NMN and consult a medical practitioner at the earliest. Under no circumstances, you should abuse or overdose NMN.

The promising NMN benefits in NAD+-boosting and anti-aging have truly delighted the scientific and medical communities. In the upcoming years, more and more research on other amazing Nicotinamide Mononucleotide advantages is likely. 

We hope that these insights on the amazing NMN benefits were useful to you.